Stanford Medicine
Longo Lab Informatics
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Mice models

Several Alzheimer's Disease mouse models in our projects. See here for more information.

PS19

PS19 (B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J) Transgenic (Tg) mice express the P301S mutant form of human tau and develop progressive accumulation of neurofibrillary tangles with age. Thus, the strain is commonly used as a model of tauopathy, such as Alzheimer's Disease.

T41B

The line 41 of mThy1-hAPPLond/swe mouse (hAPP751+) is a transgenic mouse model of AD expressing high level of human APP751 cDNA containing the London (V717I) and Swedish (K670M/N671L) mutations under the regulatory control of the murine (m)Thy-1 gene.

5XFAD

Coming soon...

Drug compounds

Therapeutic compounds being developed by the Longo Lab.

LM11A-C31 (C31)

C31 targets p75 neurotrophin receptor.

PTX-BD10-2 (BD10-2)

BD10-2 targets TRK neurotrophin receptors.

PTX-BD10-3 (BD10-3)

BD10-3 targets TRK neurotrophin receptors.

Projects

Below is a list of past and ongoing projects with sequencing data. See here for more information.