PS19 (B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J) Transgenic (Tg) mice express the P301S mutant form of human tau and develop progressive accumulation of neurofibrillary tangles with age. Thus, the strain is commonly used as a model of tauopathy, such as Alzheimer's Disease.
The line 41 of mThy1-hAPPLond/swe mouse (hAPP751+) is a transgenic mouse model of AD expressing high level of human APP751 cDNA containing the London (V717I) and Swedish (K670M/N671L) mutations under the regulatory control of the murine (m)Thy-1 gene.
Coming soon...
C31 targets p75 neurotrophin receptor.
BD10-2 targets TRK neurotrophin receptors.
BD10-3 targets TRK neurotrophin receptors.
9 month old PS19 mice were treated with C31 and long-term potentiation (LTP) stimulation. Hippocampal tissue was collected 24 hours after last dose and bulk sequencing was performed.
16 month old T41B mice were treated with BD10-2 and long-term potentiation (LTP) stimulation. Hippocampal tissue was collected 24 hours after last dose and bulk sequencing was performed.
9 month old PS19 mice were treated with C31. Hippocampal tissue was collected 1 hour after last dose and bulk sequencing was performed.
16 month old T41B mice were treated with BD10-2. Hippocampal tissue was collected 1 hour after last dose and bulk sequencing was performed.
4, 12, and 23 month old T41B mice were treated with C31. Hippocampal tissue was collected 1 hour after last dose and bulk sequencing was performed.
9 month old PS19 mice were treated with C31. Cortical tissue was collected 1 hour after last dose and single-cell sequencing was performed.
12 month old T41B mice were treated with C31. Cortical tissue was collected 1 hour after last dose and single-cell sequencing was performed.